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Optimization of episomal reprogramming for generation of human induced pluripotent stem cells from fibroblasts

4 Mar 2018

Abstract excerpt

Generation of induced pluripotent stem cells (iPSCs) by defined factors (OCT4, SOX2, C-MYC, and KLF4) from various human primary cells has been reported. Human fibroblasts have been widely used as a cellular source in reprogramming studies over recent decades. The original method of iPSC generation uses retro- or lentivirus vectors that require integration of viral DNA into the target cells. The integration of...

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PMID: 30460090
DOI: 10.1080/19768354.2018.1451367

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