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Article

Influence of DNA methylation on the expression of OPG/RANKL in primary osteoporosis

1 Jan 2018

Abstract excerpt

A key factor in regulating bone absorption is the proportion of RANKL/OPG. Although many reports showing diverse transcription factors or epigenetic modification could be responsible for regulating RANKL&OPG ratio, there is still little exploration on promoter methylation status of both genes in osteoporotic bone tissues. Our aim is to investigate the changes of methylation in CpG island of these genes' promoters...

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PMID: 30443169
DOI: 10.7150/ijms.27333

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