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Article

Clinical significance of APOB inactivation in hepatocellular carcinoma

1 Nov 2018

Abstract excerpt

Recent findings from The Cancer Genome Atlas project have provided a comprehensive map of genomic alterations that occur in hepatocellular carcinoma (HCC), including unexpected mutations in apolipoprotein B (APOB). We aimed to determine the clinical significance of this non-oncogenetic mutation in HCC. An Apob gene signature was derived from genes that differed between control mice and mice treated with siRNA...

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PMID: 30429453
DOI: 10.1038/s12276-018-0174-2

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