Article
Epigenomic and somatic mutations of pituitary tumors with clinical and pathological correlations in 111 patients.
Clinical endocrinology - 1 Dec 2022
Guaraldi Federica, Morandi Luca, Zoli Matteo, Mazzatenta Diego, Righi Alberto, Evangelisti Stefania, Ambrosi Francesca, Tonon Caterina, Giannini Caterina, Lloyd Ricardo V, Asioli Sofia
Abstract excerpt
OBJECTIVE: To profile clinically non-aggressive and aggressive pituitary adenomas (PAs)/pituitary neuroendocrine tumours (PitNETs) and pituitary carcinomas for somatic mutations and epigenetic alterations of genes involved in cell proliferation/differentiation, microRNAs (miRNA)/long noncoding RNA (LncRNA)-post-transcriptional regulators and therapy targets. DESIGN: Retrospective observational study. PATIENTS AND...
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