Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Role of the critical period in sex and brain differentiation: learning from dioxin-induced disorders in next generations].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan - 1 Jan 2014

Yamada Hideyuki, Takeda Tomoki, Koga Takayuki, Ishii Yuji

Abstract excerpt

The sexual differentiation of animal fetuses and infants needs stimuli by sex steroids, which are produced in their own gonads, during a short window ('critical period') of pre- and post-natal periods. Our laboratory has conducted a series of studies focusing on the damage to next generations by dioxins. When pregnant rats are exposed to a prototype of dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; 1 μg/kg),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Luteinizing Hormone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Pregnancy

Share to Prenatal Exposure Delayed Effects

Share to Sexual Maturation

Source

Identifiers

PMID: 24694814
DOI: 10.1248/yakushi.13-00251-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Role of the critical period in sex and brain differentiation: learning from dioxin-induced disorders in next generations].PMID 24694814Read ↗

Maternal Exposure to Dioxin Imprints Sexual Immaturity of the Pups through Fixing the Status of the Reduced Expression of Hypothalamic Gonadotropin-Releasing HormoneSemantic proximity Read ↗

Workshop to identify critical windows of exposure for children's health: reproductive health in children and adolescents work group summary.Semantic proximity Read ↗

Endocrine Disruptor Chemicals and Children’s HealthSemantic proximity Read ↗

Experimental Evidence of 2,3,7,8-Tetrachlordibenzo-p-Dioxin (TCDD) Transgenerational Effects on Reproductive HealthSemantic proximity Read ↗

Potential of environmental factors to affect development of reproductive systems.Semantic proximity Read ↗

Critical windows of exposure for children's health: the reproductive system in animals and humans.Semantic proximity Read ↗

Multigenerational and Transgenerational Effects of DioxinsSemantic proximity Read ↗

Early Life Exposure to the Mycotoxin Fumonisin B1 and Developmental Programming of the Ovary of the Offspring: The Possible Role of Autophagy in Fertility RecoverySemantic proximity Read ↗

Multi- and Transgenerational Outcomes of an Exposure to a Mixture of Endocrine-Disrupting Chemicals (EDCs) on Puberty and Maternal Behavior in the Female RatSemantic proximity Read ↗

Genetic background and window of exposure contribute to thyroid dysfunction promoted by low-dose exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice.Semantic proximity Read ↗

A single prenatal exposure to the endocrine disruptor 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin alters developmental myelination and remyelination potential in the rat brainSemantic proximity Read ↗

Susceptibility in utero and upon neonatal exposure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.