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Article

Transcription factors and stress response gene alterations in human keratinocytes following Solar Simulated Ultra Violet Radiation

13 Oct 2017

Abstract excerpt

Ultraviolet radiation (UVR) from sunlight is the major effector for skin aging and carcinogenesis. However, genes and pathways altered by solar-simulated UVR (ssUVR), a mixture of UVA and UVB, are not well characterized. Here we report global changes in gene expression as well as associated pathways and upstream transcription factors in human keratinocytes exposed to ssUVR. Human HaCaT keratinocytes were exposed...

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PMID: 29051608
DOI: 10.1038/s41598-017-13765-7

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