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Flaviviruses have imperfect icosahedral symmetry

22 Oct 2018

Abstract excerpt

Flaviviruses assemble initially in an immature, noninfectious state and undergo extensive conformational rearrangements to generate mature virus. Previous cryo-electron microscopy (cryo-EM) structural studies of flaviviruses assumed icosahedral symmetry and showed the concentric organization of the external glycoprotein shell, the lipid membrane, and the internal nucleocapsid core. We show here that when...

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PMID: 30348794
DOI: 10.1073/pnas.1809304115

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