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Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation

5 Oct 2018

Abstract excerpt

lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of...

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PMID: 30345355
DOI: 10.1126/sciadv.aat5869

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