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Disruption of ADAM3 Impairs the Migration of Sperm into Oviduct in Mouse1

2 Apr 2009

Abstract excerpt

Sperm from four different gene-disrupted mouse lines (calmegin [Clgn], Adam1a, Adam2, and Ace) are known to have defective zona-binding ability. Moreover, it is also reported that the sperm from all of these mouse lines exhibit another common phenotype of impaired migration into oviduct despite the large number of sperm found in uterus after coitus. On the other hand, the sperm from the Adam3-disrupted mouse line...

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PMID: 19339711
DOI: 10.1095/biolreprod.108.074021

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