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Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM71

6 Aug 2015

Abstract excerpt

The mammalian epididymis is a highly convoluted tubule that connects the testis to the vas deferens. Its proper functions in sperm transport, storage, and maturation are essential for male reproduction. One of the genes predominantly expressed in the epididymis is ADAM7 (a disintegrin and metalloprotease 7). Previous studies have shown that ADAM7 synthesized in the epididymis is secreted into the epididymal lumen...

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PMID: 26246218
DOI: 10.1095/biolreprod.115.130252

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