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Article

Impact of ZBTB7A hypomethylation and expression patterns on treatment response to hydroxyurea

1 Oct 2018

Abstract excerpt

BACKGROUND: We aimed to clarify the emerging epigenetic landscape in a group of genes classified as "modifier genes" of the β-type globin genes (HBB cluster), known to operate in trans to accomplish the two natural developmental switches in globin expression, from embryonic to fetal during the first trimester of conception and from fetal to adult around the time of birth. The epigenetic alterations were...

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PMID: 30285874
DOI: 10.1186/s40246-018-0177-z

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