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Article

DMRT1 repression using a novel approach to genetic manipulation induces testicular dysgenesis in human fetal gonads

4 Sept 2018

Abstract excerpt

STUDY QUESTION: Does loss of DMRT1 in human fetal testis alter testicular development and result in testicular dysgenesis? SUMMARY ANSWER: DMRT1 repression in human fetal testis alters the expression of key testicular and ovarian determining genes, and leads to focal testicular dysgenesis. WHAT IS KNOWN ALREADY: Testicular dysgenesis syndrome (TDS) is associated with common testicular disorders in young men, but...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 30272154
DOI: 10.1093/humrep/dey289

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DMRT1 repression using a novel approach to genetic manipulation induces testicular dysgenesis in human fetal gonadsPMID 30272154Read ↗

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