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Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice

19 Sept 2018

Abstract excerpt

gene deletion in the adult mouse brain. This phenotype showed reduced length and disorganization of the hippocampal mossy fiber infrapyramidal bundle, the axonal pathway of dentate gyrus granule cells that is maintained by neurogenesis in the mouse brain. This defect in axonal organization correlated with reduced BACE1-mediated cleavage of the neural cell adhesion protein close homolog of L1 (CHL1), which has...

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PMID: 30232227
DOI: 10.1126/scitranslmed.aao5620

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