Article
Defining hrHPV genotypes in cervical intraepithelial neoplasia by laser capture microdissection supports reflex triage of self-samples using HPV16/18 and FAM19A4/miR124-2 methylation.
Gynecologic oncology - 1 Nov 2018
Leeman Annemiek, Ebisch Renée M F, Kasius Annemieke, Bosgraaf Remko P, Jenkins David, van de Sandt Miekel M, de Strooper Lise M A, Heideman Daniëlle A M, Snijders Peter J F, Massuger Leon F A G, Bekkers Ruud L M, Meijer Chris J L M, van Kemenade Folkert J, Quint Wim G V, Melchers Willem J G
Abstract excerpt
OBJECTIVE: HPV16/18 genotyping and detection of hypermethylation of human cell genes involved in cervical oncogenesis have shown promising results in triage of high-risk HPV (hrHPV)-screen positive women on cervical smears. These tests can be performed on self-samples, which contain cervical and vaginal cells. We studied whether a self-sample represents the hrHPV type causing the worst cervical lesion and whether...
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