Article
TMPRSS2:ERG gene fusion expression regulates bone markers and enhances the osteoblastic phenotype of prostate cancer bone metastases.
Cancer letters - 1 Dec 2018
Delliaux Carine, Tian Tian V, Bouchet Mathilde, Fradet Anais, Vanpouille Nathalie, Flourens Anne, Deplus Rachel, Villers Arnauld, Leroy Xavier, Clézardin Philippe, de Launoit Yvan, Bonnelye Edith, Duterque-Coquillaud Martine
Abstract excerpt
Prostate cancers have a strong propensity to metastasize to bone and promote osteoblastic lesions. TMPRSS2:ERG is the most frequent gene rearrangement identified in prostate cancer, but whether it is involved in prostate cancer bone metastases is largely unknown. We exploited an intratibial metastasis model to address this issue and we found that ectopic expression of the TMPRSS2:ERG fusion enhances the ability...
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