Article
The involvement of the low-oxygen-activated locus of Burkholderia cenocepacia in adaptation during cystic fibrosis infection.
Scientific reports - 6 Sept 2018
Cullen Louise, O'Connor Andrew, McCormack Sarah, Owens Rebecca A, Holt Giles S, Collins Cassandra, Callaghan Máire, Doyle Sean, Smith Darren, Schaffer Kirsten, Fitzpatrick David A, McClean Siobhán
Abstract excerpt
Chronic infection with opportunistic pathogens including Burkholderia cepacia complex (Bcc) is a hallmark of cystic fibrosis (CF). We investigated the adaptive mechanisms facilitating chronic lung infection in sequential Bcc isolates from two siblings with CF (P1 and P2), one of whom also experienced intermittent blood-stream infections (P2). We previously showed increased lung cell attachment with colonisation...
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