The Role of Mucoidy in Virulence of Bacteria from theBurkholderia cepaciaComplex: A Systematic Proteomic and Transcriptomic Analysis

Abstract excerpt

Bacteria of the Burkholderia cepacia complex (BCC) are associated with severe infection in cystic fibrosis. Recent evidence shows that the mucoid phenotype is common in BCC bacteria; however, during chronic infection, transitions from the mucoid to nonmucoid morphology have been shown to take place. Here we use RNA microarray and proteomic isobaric tagging relative and absolute quantitation technologies to gain...

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