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Nuclear Respiratory Factor 1 (NRF-1) Controls the Activity Dependent Transcription of the GABA-A Receptor Beta 1 Subunit Gene in Neurons

21 Aug 2018

Abstract excerpt

While the exact role of Beta 1 subunit-containing GABA-A receptors (GABARs) in brain function is not well understood, altered expression of the Beta 1 subunit gene (GABRB1) is associated with neurological and neuropsychiatric disorders. In particular, down-regulation of Beta 1 subunit levels is observed in brains of patients with epilepsy, autism, bipolar disorder, and schizophrenia. A pathophysiological feature...

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PMID: 30186109
DOI: 10.3389/fnmol.2018.00285

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