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Article

Selective Pressure for Biofilm Formation in Bacillus subtilis: Differential Effect of Mutations in the Master Regulator SinR on Bistability.

mBio - 4 Sept 2018

Kampf Jan, Gerwig Jan, Kruse Kerstin, Cleverley Robert, Dormeyer Miriam, Grünberger Alexander, Kohlheyer Dietrich, Commichau Fabian M, Lewis Richard J, Stülke Jörg

Abstract excerpt

Biofilm formation by Bacillus subtilis requires the expression of genes encoding enzymes for extracellular polysaccharide synthesis and for an amyloid-like protein. The master regulator SinR represses all the corresponding genes, and repression of these key biofilm genes is lifted when SinR interacts with its cognate antagonist proteins. The YmdB phosphodiesterase is a recently discovered factor that is involved...

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Identifiers

PMID: 30181249
DOI: 10.1128/mBio.01464-18
PMCID: PMC6123443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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