Article
Green fluorescent proteins engineered for cartilage-targeted drug delivery: Insights for transport into highly charged avascular tissues.
Biomaterials - 1 Nov 2018
Krishnan Yamini, Rees Holly A, Rossitto Christina P, Kim Si-Eun, Hung Han-Hwa K, Frank Eliot H, Olsen Bradley D, Liu David R, Hammond Paula T, Grodzinsky Alan J
Abstract excerpt
Osteoarthritis (OA), the most common form of arthritis, is a multi-factorial disease that primarily affects cartilage as well as other joint tissues such as subchondral bone. The lack of effective drug delivery, due to the avascular nature of cartilage and the rapid clearance of intra-articularly delivered drugs via the synovium, remains a major challenge in the development of disease modifying drugs for OA....
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