Article
EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer.
Nature communications - 29 Aug 2018
Wang Li, Saci Abdel, Szabo Peter M, Chasalow Scott D, Castillo-Martin Mireia, Domingo-Domenech Josep, Siefker-Radtke Arlene, Sharma Padmanee, Sfakianos John P, Gong Yixuan, Dominguez-Andres Ana, Oh William K, Mulholland David, Azrilevich Alex, Hu Liangyuan, Cordon-Cardo Carlos, Salmon Hélène, Bhardwaj Nina, Zhu Jun, Galsky Matthew D
Abstract excerpt
Cancers infiltrated with T-cells are associated with a higher likelihood of response to PD-1/PD-L1 blockade. Counterintuitively, a correlation between epithelial-mesenchymal transition (EMT)-related gene expression and T-cell infiltration has been observed across tumor types. Here we demonstrate, using The Cancer Genome Atlas (TCGA) urothelial cancer dataset, that although a gene expression-based measure of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.