Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Zinc signalling and subcellular distribution: emerging targets in type 2 diabetes.

Trends in molecular medicine - 1 Oct 2008

Mocchegiani Eugenio, Giacconi Robertina, Malavolta Marco

Abstract excerpt

A finely tuned subcellular distribution of zinc (Zn), through the coordinated action of Zn transporters (ZnTs) and metallothioneins (MTs), is crucial for optimal cell function. Dysfunctions of these proteins might act as key causative or promoting factors in several chronic pathologies. Evidence of their involvement in the pathogenesis of type 2 diabetes (DM2) is emerging. The association of single nucleotide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cation Transport Proteins
Share to Diabetes Mellitus, Type 2
Share to Metallothionein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Biological

Share to Polymorphism, Single Nucleotide

Share to Zinc Transporter 8

Source

Identifiers

PMID: 18774338
DOI: 10.1016/j.molmed.2008.08.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zinc signalling and subcellular distribution: emerging targets in type 2 diabetes.PMID 18774338Read ↗

Comparative Roles of ZIP and ZnT Zinc Transporters in Metabolic InflammationSemantic proximity Read ↗

Zinc and its transporters, pancreatic β-cells, and insulin metabolism.Semantic proximity Read ↗

Role of zinc and zinc transporters in the molecular pathogenesis of diabetes mellitus.Semantic proximity Read ↗

The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and Perspective.Semantic proximity Read ↗

Disturbed zinc homeostasis in diabetic patients by in vitro and in vivo analysis of insulinomimetic activity of zinc.Semantic proximity Read ↗

ZnT8 Haploinsufficiency Impacts MIN6 Cell Zinc Content and β-Cell Phenotype via ZIP-ZnT8 Coregulation.Semantic proximity Read ↗

Lipid-tuned Zinc Transport Activity of Human ZnT8 Protein Correlates with Risk for Type-2 Diabetes.Semantic proximity Read ↗

Manganese transport in mammals by zinc transporter family proteins, ZNT and ZIP.Semantic proximity Read ↗

Exploring the Association Between Demographics, SLC30A8 Genotype, and Human Islet Content of Zinc, Cadmium, Copper, Iron, Manganese and Nickel.Semantic proximity Read ↗

Current understanding of ZIP and ZnT zinc transporters in human health and diseases.Semantic proximity Read ↗

Emerging Roles of Metallothioneins in Beta Cell Pathophysiology: Beyond and above Metal Homeostasis and Antioxidant ResponseSemantic proximity Read ↗

Zinc fluxes and zinc transporter genes in chronic diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.