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Article

Fatal Central Nervous System Lymphocytic Vasculitis after Treatment for Burkitt Lymphoma in a Patient with a SH2D1A Mutation.

The Pediatric infectious disease journal - 1 Feb 2019

Neves João Farela, Raga Lamberto Torralba, Chiang Samuel C C, Tesi Bianca, Vieira José Pedro, Cordeiro Ana Isabel, Borrego Luis, Bryceson Yenan T

Abstract excerpt

Very rarely, patients with X-linked lymphoproliferative syndrome type 1 present central nervous system vasculitis. We report a patient carrying a SH2D1A mutation that, after treatment for lymphoma developed fatal central nervous system vasculitis. He lacked signs of ongoing Epstein-Barr virus infection. We propose that impaired T cell homeostasis caused by SAP deficiency facilitates aberrant CD8 T cell activation...

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Source

Identifiers

PMID: 30138256
DOI: 10.1097/INF.0000000000002154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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