Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Reality of Multiple Endocrine Neoplasia Type 2B Diagnosis: Awareness of Unique Physical Appearance Is Important.

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi - 1 Jan 2018

Nagaoka Ryuta, Sugitani Iwao, Sanada Marie, Jikuzono Tomoo, Okamura Ritsuko, Igarashi Takehito, Akasu Haruki, Shimizu Kazuo

Abstract excerpt

BACKGROUND: Multiple endocrine neoplasia type 2B (MEN2B) is an extremely rare syndrome mainly caused by RET918 germline mutations. MEN2B typically causes medullary thyroid carcinoma (MTC), pheochromocytoma, and unique physical characteristics including mucosal neuroma, distinctive facial appearance, and Marfanoid habitus. Most patients have abdominal symptoms such as bloating, intermittent constipation, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Adrenal Gland Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Multiple Endocrine Neoplasia Type 2b

Share to Pheochromocytoma

Share to Proto-Oncogene Proteins c-ret

Share to Thyroid Neoplasms

Share to Tongue

Source

Identifiers

PMID: 30135345
DOI: 10.1272/jnms.JNMS.2018_85-26

Genes

RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Reality of Multiple Endocrine Neoplasia Type 2B Diagnosis: Awareness of Unique Physical Appearance Is Important.PMID 30135345Read ↗

Early diagnosis of multiple endocrine neoplasia type 2B: a challenge for physicians.Semantic proximity Read ↗

Multiple Endocrine Neoplasia Type 2B: Early Diagnosis by Multiple Mucosal Neuroma and Its DNA AnalysisSemantic proximity Read ↗

Phenotypic multiple endocrine neoplasia type 2B, without endocrinopathy or RET gene mutation: implications for management.Semantic proximity Read ↗

Failure to recognize multiple endocrine neoplasia 2B: more common than we think?Semantic proximity Read ↗

Multiple endocrine neoplasia type 2: an overview.Semantic proximity Read ↗

Multiple endocrine neoplasia type 2B--genetic basis and clinical expression.Semantic proximity Read ↗

Multiple endocrine neoplasia type 2B: more than an endocrine disorder.Semantic proximity Read ↗

MEN2B syndrome - paediatric case report.Semantic proximity Read ↗

Multiple endocrine neoplasia-IIb with RET gene mutation p.M918T： A case report.Semantic proximity Read ↗

Molecular Diagnosis and Treatment of Multiple Endocrine Neoplasia Type 2B in Ethnic Han Chinese.Semantic proximity Read ↗

[Clinical manifestations, therapeutic response to tyrosinase inhibitor and RET gene activating mutation in a patient with multiple endocrine neoplasia 2B].Semantic proximity Read ↗

Extra-Endocrine Features in Infancy as Early Clues to MEN2B.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.