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Article

Molecular Diagnosis and Treatment of Multiple Endocrine Neoplasia Type 2B in Ethnic Han Chinese.

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2021

Zhang Zhe-Wei, Guo Xiao, Qi Xiao-Ping

Abstract excerpt

BACKGROUND: Multiple endocrine neoplasia type 2B (MEN 2B) is mainly caused by M918T RET germline mutation, and characterized by medullary thyroid carcinoma (MTC), pheochromocytoma (PHEO) and non-endocrine features. However, the diagnosis and treatment are usually delayed. METHODS: This study reports 5 Chinese pedigrees with 5 individuals harboring germline RETM918T, and systematically reviewed previous Chinese...

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Identifiers

PMID: 32914730
DOI: 10.2174/1871530320666200910112230

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