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Article

Extra-Endocrine Features in Infancy as Early Clues to MEN2B.

Pediatrics - 1 Sept 2026

Mirra Giulia, Deodati Annalisa, Grossi Armando, Agolini Emanuele, Cappa Marco, Cianfarani Stefano, Ubertini Graziamaria

Abstract excerpt

Multiple endocrine neoplasia type 2B (MEN2B) is a rare autosomal-dominant cancer predisposition syndrome in which prognosis is strongly influenced by the stage of medullary thyroid carcinoma at diagnosis. Virtually all affected children exhibit 1 or more extra-endocrine features during childhood, offering an opportunity for timely recognition. We retrospectively reviewed 5 pediatric patients with MEN2B managed at...

Read the complete abstract on PubMed

Topics

Humans
Proto-Oncogene Mas
Multiple Endocrine Neoplasia Type 2b
Male
Infant
Female
Retrospective Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-ret

Genetic Testing

Child, Preschool

Thyroid Neoplasms

Mutation

Constipation

Source

Identifiers

PMID: 42580739
DOI: 10.1542/peds.2025-075459

Genes

RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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