Article
Activation of the apoptotic pathway during prolonged prometaphase blocks daughter cell proliferation
22 Aug 2018
Abstract excerpt
When untransformed human cells spend >1.5 h in prometaphase under standard culture conditions, all daughters arrest in G1 despite normal division of their mothers. We investigate what happens during prolonged prometaphase that leads to daughter cell arrest in the absence of DNA damage. We find that progressive loss of anti-apoptotic MCL-1 activity and oxidative stress act in concert to partially activate the...
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