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Article

HA1077 displays synergistic activity with daclatasvir against hepatitis C virus and suppresses the emergence of NS5A resistance-associated substitutions in mice.

Scientific reports - 20 Aug 2018

Lee Seung-Hoon, Moon Jae-Su, Pak Bo-Yeong, Kim Geon-Woo, Lee Wooseong, Cho Hee, Kim SangKyu, Kim Seong-Jun, Oh Jong-Won

Abstract excerpt

The kinase C-related kinase 2 (PRK2), which phosphorylates hepatitis C virus (HCV) RNA polymerase, is a proviral factor enhancing HCV replication. Here, we report on the in vivo anti-HCV efficacy of HA1077, which inhibits viral genome replication by targeting PRK2 and displays viral entry inhibitory activity by targeting Rho-associated kinase. HA1077 showed synergistic antiviral activity selectively with...

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Identifiers

PMID: 30127498
DOI: 10.1038/s41598-018-30460-3
PMCID: PMC6102265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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