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Article

Prenatal ethanol exposure causes anxiety-like phenotype and alters synaptic nitric oxide and endocannabinoid signaling in dorsal raphe nucleus of adult male rats.

Translational psychiatry - 10 Oct 2022

Oubraim Saida, Wang Ruixiang, Hausknecht Kathryn, Kaczocha Martin, Shen Roh-Yu, Haj-Dahmane Samir

Abstract excerpt

Mood disorders, including anxiety and depression caused by prenatal ethanol exposure (PE) are prevalent conditions in fetal alcohol spectrum disorders (FASDs). Prenatal ethanol exposure is associated with persistent dysfunctions of several neurotransmitter systems, including the serotonin (5-HT) system, which plays a major role in mood regulation and stress homeostasis. While PE is known to disrupt the...

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Identifiers

PMID: 36216807
DOI: 10.1038/s41398-022-02210-7
PMCID: PMC9550821

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