Article
Alternative splicing expands the prognostic impact of KRAS in microsatellite stable primary colorectal cancer.
International journal of cancer - 15 Feb 2019
Eilertsen Ina A, Sveen Anita, Strømme Jonas M, Skotheim Rolf I, Nesbakken Arild, Lothe Ragnhild A
Abstract excerpt
KRAS mutation is a well-known marker for poor response to targeted treatment and patient prognosis in microsatellite stable (MSS) colorectal cancer (CRC). However, variation in clinical outcomes among patients wild-type for KRAS underlines that this is not a homogeneous population. Here, we evaluated the prognostic impact of KRAS alternative splicing in relation to mutation status in a single-hospital series of...
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