Article
Proto-Oncogene HRAS Transcript Level and Overall Survival in Stages II and III Colorectal Cancer.
Cancer medicine - 1 Aug 2025
Kim Donghyun, Sharif Saima, Garay Juan Antonio Raygoza, Bhakta Avanish S, Boland Patrick M, Cavnar Michael J, Churchman Michelle L, Hatoum Hassan, Huang Lyen C, Kim Joseph, Kim Richard, Lentz Robert W, Mukherjee Sarbajit, O'Donnell Mary T, Quartey Benjamin, Reilley Matthew J, Rounbehler Robert J, Salhia Bodour, Schneider Bryan P, Chan Carlos H
Abstract excerpt
BACKGROUND: Mutational landscape is prognostic in colorectal cancer (CRC). Rat sarcoma (RAS) oncogenes, such as KRAS and NRAS, with driver mutations, portend poor survival outcomes, whereas pathologic mutations in HRAS are extremely rare, and their prognostic value remains uncertain. METHODS: This retrospective study analyzed the Oncology Research Information Exchange Network (ORIEN) alliance tumor RNA-Seq data...
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