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Article

Widespread Decrease of Type 1 Cannabinoid Receptor Availability in Huntington Disease In Vivo

18 Aug 2010

Abstract excerpt

UNLABELLED: The type 1 cannabinoid receptor (CB1) is a crucial modulator of synaptic transmission in the brain. Animal and postmortem human data suggest that mutant huntingtin represses CB1 transcription. Our aim was to measure CB1 levels in the brains of Huntington disease (HD) patients in vivo. METHODS: Twenty symptomatic HD patients and 14 healthy controls underwent PET with the novel CB1 ligand...

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PMID: 20720046
DOI: 10.2967/jnumed.110.077156

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