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Article

Adaptive Evolution of MERS-CoV to Species Variation in DPP4.

Cell reports - 14 Aug 2018

Letko Michael, Miazgowicz Kerri, McMinn Rebekah, Seifert Stephanie N, Sola Isabel, Enjuanes Luis, Carmody Aaron, van Doremalen Neeltje, Munster Vincent

Abstract excerpt

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) likely originated in bats and passed to humans through dromedary camels; however, the genetic mechanisms underlying cross-species adaptation remain poorly understood. Variation in the host receptor, dipeptidyl peptidase 4 (DPP4), can block the interaction with the MERS-CoV spike protein and form a species barrier to infection. To better understand the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30110630
DOI: 10.1016/j.celrep.2018.07.045
PMCID: PMC7104223

Genes

DPP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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