Article
A pre-microRNA-149 (miR-149) genetic variation affects miR-149 maturation and its ability to regulate the Puma protein in apoptosis.
The Journal of biological chemistry - 13 Sept 2013
Ding Su-Ling, Wang Jian-Xun, Jiao Jian-Qin, Tu Xin, Wang Qing, Liu Fang, Li Qian, Gao Jie, Zhou Qun-Yong, Gu Dong-Feng, Li Pei-Feng
Abstract excerpt
MicroRNAs (miRNAs) are small, single-stranded, noncoding RNAs that function as negative regulators of gene expression. They are transcribed from endogenous DNA and form hairpin structures (termed as pre-miRNAs) that are processed to form mature miRNAs. It remains largely unknown as to the molecular consequences of the natural genetic variation in pre-miRNAs. Here, we report that an A→G polymorphism (rs71428439)...
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