Article
Diverse Non-genetic, Allele-Specific Expression Effects Shape Genetic Architecture at the Cellular Level in the Mammalian Brain.
Neuron - 8 Mar 2017
Huang Wei-Chao, Ferris Elliott, Cheng Tong, Hörndli Cornelia Stacher, Gleason Kelly, Tamminga Carol, Wagner Janice D, Boucher Kenneth M, Christian Jan L, Gregg Christopher
Abstract excerpt
Interactions between genetic and epigenetic effects shape brain function, behavior, and the risk for mental illness. Random X inactivation and genomic imprinting are epigenetic allelic effects that are well known to influence genetic architecture and disease risk. Less is known about the nature, prevalence, and conservation of other potential epigenetic allelic effects in vivo in the mouse and primate brain. Here...
Topics
- Alleles
- Animals
- Brain
- Genetic Variation
- Genomic Imprinting
- Genotype
- Humans
- Macaca
- Mammals
- Mice, Transgenic
- Mutation