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Prodrug suicide gene therapy for cancer targeted intracellular by mesenchymal stem cell exosomes

11 Aug 2018

Abstract excerpt

The natural behavior of mesenchymal stem cells (MSCs) and their exosomes in targeting tumors is a promising approach for curative therapy. Human tumor tropic mesenchymal stem cells (MSCs) isolated from various tissues and MSCs engineered to express the yeast cytosine deaminase::uracil phosphoribosyl transferase suicide fusion gene (yCD::UPRT-MSCs) released exosomes in conditional medium (CM). Exosomes from all...

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PMID: 30098225
DOI: 10.1002/ijc.31792

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