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Article

MicroRNA-124 Dysregulation Is Associated With Retinal Inflammation and Photoreceptor Death in the Degenerating Retina

1 Aug 2018

Abstract excerpt

Purpose: We sought to determine the role and retinal cellular location of microRNA-124 (miR-124) in a neuroinflammatory model of retinal degeneration. Further, we explored the anti-inflammatory relationship of miR-124 with a predicted messenger RNA (mRNA) binding partner, chemokine (C-C motif) ligand 2 (Ccl2), which is crucially involved in inflammatory cell recruitment in the damaged retina. Methods: Human AMD...

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PMID: 30098196
DOI: 10.1167/iovs.18-24623

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