Simplified Canadian Definition for Familial Hypercholesterolemia.

doi:10.1016/j.cjca.2018.05.015

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Article

Simplified Canadian Definition for Familial Hypercholesterolemia.

The Canadian journal of cardiology - 1 Sept 2018

Ruel Isabelle, Brisson Diane, Aljenedil Sumayah, Awan Zuhier, Baass Alexis, Bélanger Alexandre, Bergeron Jean, Bewick David, Brophy James M, Brunham Liam R, Couture Patrick, Dufour Robert, Francis Gordon A, Frohlich Jiri, Gagné Claude, Gaudet Daniel, Grégoire Jean C, Gupta Milan, Hegele Robert A, Mancini G B John, McCrindle Brian W, Pang Jing, Raggi Paolo, Tu Jack V, Watts Gerald F, Genest Jacques

Abstract excerpt

Familial hypercholesterolemia (FH) is an autosomal codominant lipoprotein disorder characterized by elevated low-density lipoprotein cholesterol (LDL-C) and high risk of premature atherosclerotic cardiovascular disease. Definitions for FH rely on complex algorithms that are on the basis of levels of total or LDL-C, clinical features, family history, and DNA analysis that are often difficult to obtain. We propose...

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PMID: 30093300
DOI: 10.1016/j.cjca.2018.05.015

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APOB
LDLR
PCSK9

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