Article
Long-term exposure to insulin and volumetric mammographic density: observational and genetic associations in the Karma study.
Breast cancer research : BCR - 9 Aug 2018
Borgquist Signe, Rosendahl Ann H, Czene Kamila, Bhoo-Pathy Nirmala, Dorkhan Mozhgan, Hall Per, Brand Judith S
Abstract excerpt
BACKGROUND: Long-term insulin exposure has been implicated in breast cancer etiology, but epidemiological evidence remains inconclusive. The aims of this study were to investigate the association of insulin therapy with mammographic density (MD) as an intermediate phenotype for breast cancer and to assess associations with long-term elevated circulating insulin levels using a genetic score comprising 18...
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