Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Perampanel chronic treatment does not induce tolerance and decreases tolerance to clobazam in genetically epilepsy prone rats.

Epilepsy research - 1 Oct 2018

Citraro Rita, De Sarro Caterina, Leo Antonio, Donato di Paola Eugenio, Palma Ernesto, Russo Emilio, De Sarro Giovambattista

Abstract excerpt

Tolerance to some therapeutic effects of antiepileptic drugs may account for the development of pharmacoresistance in patients with epilepsy. In the present study, following oral acute pretreatment with the new antiepileptic drug perampanel (0.1, 0.3, 1 or 3 mg/kg), we observed that the drug significantly and dose-dependently attenuated the seizure phases (clonus and tonus) of audiogenic seizures in genetically...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acoustic Stimulation
Share to Administration, Oral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Anticonvulsants

Share to Drug Tolerance

Share to Epilepsy, Reflex

Share to Nitriles

Share to Pyridones

Share to Seizures

Source

Identifiers

PMID: 30092489
DOI: 10.1016/j.eplepsyres.2018.07.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Perampanel chronic treatment does not induce tolerance and decreases tolerance to clobazam in genetically epilepsy prone rats.PMID 30092489Read ↗

Lack of development of tolerance to anticonvulsant effects of two excitatory amino acid antagonists, CGP [corrected] 37849 and CGP 39551 in genetically epilepsy-prone rats.Semantic proximity Read ↗

Modulation of audiogenically kindled seizures by gamma-aminobutyric acid-related mechanisms in the amygdala.Semantic proximity Read ↗

GAERS are resistant to migraine-provoking agents: The role of extrasynaptic GABAA receptorsSemantic proximity Read ↗

Amiloride and SN-6 suppress audiogenic seizure susceptibility in genetically epilepsy-prone rats.Semantic proximity Read ↗

Glutamatergic activation of the amygdala differentially mimics the effects of audiogenic seizure kindling in two substrains of genetically epilepsy-prone rats.Semantic proximity Read ↗

Ontogenetic study of metaphit-induced audiogenic seizures in rats.Semantic proximity Read ↗

Extrasynaptic δGABAA receptors mediate resistance to migraine-like phenotype in rats.Semantic proximity Read ↗

Audiogenic epilepsy in mice with different genotypes after neonatal treatments enhancing neurogenesis in dentate gyrus.Semantic proximity Read ↗

Clonic Seizures in GAERS Rats after Oral Administration of Enrofloxacin.Semantic proximity Read ↗

Continuous administration of antisense oligonucleotides to c-fos reduced the development of seizure susceptibility after ethacrynic acid-induced seizure in mice.Semantic proximity Read ↗

[Laboratory rat selection for the trait "the absence of audiogenic seizure proneness"].Semantic proximity Read ↗

Differential roles in the neuronal network for audiogenic seizures are observed among the inferior colliculus subnuclei and the amygdala.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.