Article
Differentiation of diabetic foot ulcer-derived induced pluripotent stem cells reveals distinct cellular and tissue phenotypes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2019
Kashpur Olga, Smith Avi, Gerami-Naini Behzad, Maione Anna G, Calabrese Rossella, Tellechea Ana, Theocharidis Georgios, Liang Liang, Pastar Irena, Tomic-Canic Marjana, Mooney David, Veves Aristidis, Garlick Jonathan A
Abstract excerpt
Diabetic foot ulcers (DFUs) are a major complication of diabetes, and there is a critical need to develop novel cell- and tissue-based therapies to treat these chronic wounds. Induced pluripotent stem cells (iPSCs) offer a replenishing source of allogeneic and autologous cell types that may be beneficial to improve DFU wound-healing outcomes. However, the biologic potential of iPSC-derived cells to treat DFUs has...
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