Article
Chronic lymphocytic leukemia with proliferation centers in bone marrow is associated with younger age at initial presentation, complex karyotype, and TP53 disruption.
Human pathology - 1 Dec 2018
Garces Sofia, Khoury Joseph D, Kanagal-Shamanna Rashmi, Salem Alireza, Wang Sa A, Ok Chi Young, Hu Shimin, Patel Keyur P, Routbort Mark J, Luthra Rajyalakshmi, Tang Guilin, Schlette Ellen J, Bueso-Ramos Carlos E, Medeiros L Jeffrey, Loghavi Sanam
Abstract excerpt
The presence of expanded proliferation centers (PCs) in lymph nodes involved by chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma has been associated with adverse clinical outcomes, but the frequency and significance of PCs in bone marrow (BM) remain unclear. The study group included 36 patients with BM involvement by CLL in which PCs were present. We compared this group with 110 randomly selected BM...
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