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Article

Birthweight, time-varying adiposity growth and early menarche in girls: A Mendelian randomisation and mediation analysis.

Obesity research & clinical practice - 1 Jan 2000

Fan Hsien-Yu, Huang Yen-Tsung, Hsieh Rong-Hong, Chao Jane C-J, Tung Yi-Ching, Lee Yungling L, Chen Yang-Ching

Abstract excerpt

OBJECTIVE: To explore the causal effect of time-varying z-BMI growth on early menarche using Mendelian randomisation (MR); to identify critical adiposity predictors of early menarche; to compare the effects of birthweight and time-varying z-BMI growth as mediators of the path from genes to early menarche using mediation analysis. METHODS: We used data from the Taiwan Children Health Study with 21 obesity-related...

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PMID: 30082248
DOI: 10.1016/j.orcp.2018.07.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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