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Article

AAV9-mediated Rbm24 overexpression induces fibrosis in the mouse heart.

Scientific reports - 3 Aug 2018

van den Hoogenhof Maarten M G, van der Made Ingeborg, de Groot Nina E, Damanafshan Amin, van Amersfoorth Shirley C M, Zentilin Lorena, Giacca Mauro, Pinto Yigal M, Creemers Esther E

Abstract excerpt

The RNA-binding protein Rbm24 has recently been identified as a pivotal splicing factor in the developing heart. Loss of Rbm24 in mice disrupts cardiac development by governing a large number of muscle-specific splicing events. Since Rbm24 knockout mice are embryonically lethal, the role of Rbm24 in the adult heart remained unexplored. Here, we used adeno-associated viruses (AAV9) to investigate the effect of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30076363
DOI: 10.1038/s41598-018-29552-x
PMCID: PMC6076270

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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