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DNA methylation and the epigenetic clock in relation to physical frailty in older people: the Lothian Birth Cohort 1936

3 Aug 2018

Abstract excerpt

BACKGROUND: The biological mechanisms underlying frailty in older people are poorly understood. There is some evidence to suggest that DNA methylation patterns may be altered in frail individuals. METHODS: Participants were 791 people aged 70 years from the Lothian Birth Cohort 1936. DNA methylation was measured in whole blood. Biological age was estimated using two measures of DNA methylation-based age...

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Share to Epigenetics and DNA Methylation
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PMID: 30075802
DOI: 10.1186/s13148-018-0538-4

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