Article
Association of Uveal Melanoma Metastatic Rate With Stochastic Mutation Rate and Type of Mutation.
JAMA ophthalmology - 1 Oct 2018
Szalai Eszter, Jiang Yi, van Poppelen Natasha M, Jager Martine J, de Klein Annelies, Kilic Emine, Grossniklaus Hans E
Abstract excerpt
Importance: It is necessary to understand the mechanisms of metastasis of uveal melanoma to advise patients and develop treatments for this tumor. Objective: To examine the stochastic properties of primary uveal melanoma including the mutation rate as a function of tumor size and metastatic rate relative to the type of mutation. Design, Setting, and Participants: We computed the mutation rate in different sized...
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