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Article

Spontaneous point mutations in the capsule synthesis locus leading to structural and functional changes of the capsule in serogroup A meningococcal populations.

Virulence - 1 Jan 2018

Ispasanie Emma, Micoli Francesca, Lamelas Araceli, Keller Dominique, Berti Francesco, De Riccio Riccardo, Di Benedettoi Roberta, Rondini Simona, Pluschke Gerd

Abstract excerpt

Whole genome sequencing analysis of 100 Neisseria meningitidis serogroup A isolates has revealed that the csaABCD-ctrABCD-ctrEF capsule polysaccharide synthesis locus represents a spontaneous point mutation hotspot. Structural and functional properties of the capsule of 11 carriage and two disease isolates with non-synonymous point mutations or stop codons in capsule synthesis genes were analyzed for their...

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Identifiers

PMID: 30067453
DOI: 10.1080/21505594.2018.1467710
PMCID: PMC6086313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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