Article
Statistical mechanics for metabolic networks during steady state growth.
Nature communications - 30 Jul 2018
De Martino Daniele, Mc Andersson Anna, Bergmiller Tobias, Guet Călin C, Tkačik Gašper
Abstract excerpt
Which properties of metabolic networks can be derived solely from stoichiometry? Predictive results have been obtained by flux balance analysis (FBA), by postulating that cells set metabolic fluxes to maximize growth rate. Here we consider a generalization of FBA to single-cell level using maximum entropy modeling, which we extend and test experimentally. Specifically, we define for Escherichia coli metabolism a...
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