Article
Elementary Growth Modes provide a molecular description of cellular self-fabrication.
PLoS computational biology - 1 Jan 2020
de Groot Daan H, Hulshof Josephus, Teusink Bas, Bruggeman Frank J, Planqué Robert
Abstract excerpt
In this paper we try to describe all possible molecular states (phenotypes) for a cell that fabricates itself at a constant rate, given its enzyme kinetics and the stoichiometry of all reactions. For this, we must understand the process of cellular growth: steady-state self-fabrication requires a cell to synthesize all of its components, including metabolites, enzymes and ribosomes, in proportions that match its...
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