Growth against entropy in bacterial metabolism: the phenotypic trade-off behind empirical growth rate distributions in E. coli.

Abstract excerpt

The solution space of genome-scale models of cellular metabolism provides a map between physically viable flux configurations and cellular metabolic phenotypes described, at the most basic level, by the corresponding growth rates. By sampling the solution space of E. coli's metabolic network, we show that empirical growth rate distributions recently obtained in experiments at single-cell resolution can be...

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